Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth
Identifieur interne : 005820 ( Main/Exploration ); précédent : 005819; suivant : 005821Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth
Auteurs : M. A. Bertocci [États-Unis] ; G. Bebko [États-Unis] ; T. Olino [États-Unis] ; J. Fournier [États-Unis] ; A. K. Hinze [États-Unis] ; L. Bonar [États-Unis] ; J. R. C. Almeida [États-Unis] ; S. B. Perlman [États-Unis] ; A. Versace [États-Unis] ; M. Travis [États-Unis] ; M. K. Gill [États-Unis] ; C. Demeter [États-Unis] ; V. A. Diwadkar [États-Unis] ; R. White [États-Unis] ; C. Schirda [États-Unis] ; J. L. Sunshine [États-Unis] ; L. E. Arnold [États-Unis] ; S. K. Holland [États-Unis] ; R. A. Kowatch [États-Unis] ; B. Birmaher [États-Unis] ; D. Axelson [États-Unis] ; E. A. Youngstrom [États-Unis] ; R. L. Findling [États-Unis] ; S. M. Horwitz [États-Unis] ; M. A. Fristad [États-Unis] ; M. L. Phillips [États-Unis]Source :
- Psychological medicine : (Print) [ 0033-2917 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Amygdale (système limbique) (physiopathologie), Cortex préfrontal (physiopathologie), Développement de l'adolescent (physiologie), Enfant, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Symptômes affectifs (physiopathologie), Symptômes comportementaux (physiopathologie), Études longitudinales.
- MESH :
- physiologie : Développement de l'adolescent.
- physiopathologie : Amygdale (système limbique), Cortex préfrontal, Symptômes affectifs, Symptômes comportementaux.
- Pascal (Inist)
- Adolescent, Enfant, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Trouble du comportement, Trouble de l'émotion, Cortex préfrontal, Noyau amygdalien, Amygdale, Symptomatologie, Autorégulation, Emotion émotivité, Analyse classes latentes, Croissance, Imagerie par résonance magnétique fonctionnelle, Études longitudinales.
English descriptors
- KwdEn :
- Adolescent, Adolescent Development (physiology), Affective Symptoms (physiopathology), Amygdala, Amygdala (physiopathology), Amygdaloid nucleus, Behavioral Symptoms (physiopathology), Behavioral disorder, Child, Emotion emotionality, Emotional disorder, Female, Functional magnetic resonance imaging, Growth, Humans, Latent class analysis, Longitudinal Studies, Magnetic Resonance Imaging, Male, Prefrontal Cortex (physiopathology), Prefrontal cortex, Self regulation, Symptomatology.
- MESH :
- physiology : Adolescent Development.
- physiopathology : Affective Symptoms, Amygdala, Behavioral Symptoms, Prefrontal Cortex.
- Adolescent, Child, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male.
Abstract
Background. Neuroimaging measures of behavioral and emotional dysregulation can yield biomarkers denoting developmental trajectories of psychiatric pathology in youth. We aimed to identify functional abnormalities in emotion regulation (ER) neural circuitry associated with different behavioral and emotional dysregulation trajectories using latent class growth analysis (LCGA) and neuroimaging. Method. A total of 61 youth (9-17 years) from the Longitudinal Assessment of Manic Symptoms study, and 24 healthy control youth, completed an emotional face n-back ER task during scanning. LCGA was performed on 12 biannual reports completed over 5 years of the Parent General Behavior Inventory 10-Item Mania Scale (PGBI-10M), a parental report of the child's difficulty regulating positive mood and energy. Results. There were two latent classes of PGBI-10M trajectories: high and decreasing (HighD; n=22) and low and decreasing (LowD; n=39) course of behavioral and emotional dysregulation over the 12 time points. Task performance was >89% in all youth, but more accurate in healthy controls and LowD versus HighD (p<0.001). During ER, LowD had greater activity than HighD and healthy controls in the dorsolateral prefrontal cortex, a key ER region, and greater functional connectivity than HighD between the amygdala and ventrolateral prefrontal cortex (p's<0.001, corrected). Conclusions. Patterns of function in lateral prefrontal cortical-amygdala circuitry in youth denote the severity of the developmental trajectory of behavioral and emotional dysregulation over time, and may be biological targets to guide differential treatment and novel treatment development for different levels of behavioral and emotional dysregulation in youth.
Url:
Affiliations:
- États-Unis
- Caroline du Nord, Pennsylvanie, Rhode Island
- Chapel Hill (Caroline du Nord), Pittsburgh, Providence (Rhode Island)
- Université Brown, Université de Caroline du Nord à Chapel Hill, Université de Pittsburgh
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Le document en format XML
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B." last="Perlman">S. B. Perlman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Versace, A" sort="Versace, A" uniqKey="Versace A" first="A." last="Versace">A. Versace</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Travis, M" sort="Travis, M" uniqKey="Travis M" first="M." last="Travis">M. Travis</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Gill, M K" sort="Gill, M K" uniqKey="Gill M" first="M. K." last="Gill">M. K. Gill</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Demeter, C" sort="Demeter, C" uniqKey="Demeter C" first="C." last="Demeter">C. Demeter</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospitals Case Medical Center/Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University Hospitals Case Medical Center/Case Western Reserve University</wicri:noRegion></affiliation></author><author><name sortKey="Diwadkar, V A" sort="Diwadkar, V A" uniqKey="Diwadkar V" first="V. A." last="Diwadkar">V. A. Diwadkar</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry and Behavioral Neuroscience, Wayne State University</s1><s2>Detroit, MI</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Detroit, MI</wicri:noRegion></affiliation></author><author><name sortKey="White, R" sort="White, R" uniqKey="White R" first="R." last="White">R. White</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry and Behavioral Neuroscience, Wayne State University</s1><s2>Detroit, MI</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Detroit, MI</wicri:noRegion></affiliation></author><author><name sortKey="Schirda, C" sort="Schirda, C" uniqKey="Schirda C" first="C." last="Schirda">C. Schirda</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Sunshine, J L" sort="Sunshine, J L" uniqKey="Sunshine J" first="J. L." last="Sunshine">J. L. Sunshine</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospitals Case Medical Center/Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University Hospitals Case Medical Center/Case Western Reserve University</wicri:noRegion></affiliation></author><author><name sortKey="Arnold, L E" sort="Arnold, L E" uniqKey="Arnold L" first="L. E." last="Arnold">L. E. Arnold</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, Ohio State University</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus, OH</wicri:noRegion></affiliation></author><author><name sortKey="Holland, S K" sort="Holland, S K" uniqKey="Holland S" first="S. K." last="Holland">S. K. Holland</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Cincinnati Children's Hospital Medical Center, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author><author><name sortKey="Kowatch, R A" sort="Kowatch, R A" uniqKey="Kowatch R" first="R. A." last="Kowatch">R. A. Kowatch</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>The Research Institute at Nationwide Children's Hospital</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>The Research Institute at Nationwide Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Birmaher, B" sort="Birmaher, B" uniqKey="Birmaher B" first="B." last="Birmaher">B. Birmaher</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Axelson, D" sort="Axelson, D" uniqKey="Axelson D" first="D." last="Axelson">D. Axelson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, Ohio State University</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus, OH</wicri:noRegion></affiliation></author><author><name sortKey="Youngstrom, E A" sort="Youngstrom, E A" uniqKey="Youngstrom E" first="E. A." last="Youngstrom">E. A. Youngstrom</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Psychology, University of North Carolina at Chapel Hill</s1><s2>Chapel Hill, NC</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Findling, R L" sort="Findling, R L" uniqKey="Findling R" first="R. L." last="Findling">R. L. Findling</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospitals Case Medical Center/Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University Hospitals Case Medical Center/Case Western Reserve University</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Horwitz, S M" sort="Horwitz, S M" uniqKey="Horwitz S" first="S. M." last="Horwitz">S. M. Horwitz</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Child Psychiatry, New York University School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Fristad, M A" sort="Fristad, M A" uniqKey="Fristad M" first="M. A." last="Fristad">M. A. Fristad</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, Ohio State University</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus, OH</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, M L" sort="Phillips, M L" uniqKey="Phillips M" first="M. L." last="Phillips">M. L. Phillips</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0193854</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0193854 INIST</idno><idno type="RBID">Pascal:14-0193854</idno><idno type="wicri:Area/PascalFrancis/Corpus">000784</idno><idno type="stanalyst">FRANCIS 14-0193854 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">001400</idno><idno type="wicri:Area/PascalFrancis/Curation">003E48</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000C21</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000C21</idno><idno type="wicri:doubleKey">0033-2917:2014:Bertocci M:behavioral:and:emotional</idno><idno type="wicri:Area/Main/Merge">005B44</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344801</idno><idno type="RBID">PMC:4344801</idno><idno type="wicri:Area/Pmc/Corpus">001236</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001236</idno><idno type="wicri:Area/Pmc/Curation">001211</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001211</idno><idno type="wicri:Area/Pmc/Checkpoint">001A69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A69</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001E96</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E96</idno><idno type="wicri:Area/PubMed/Curation">001E87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001E87</idno><idno type="wicri:Area/PubMed/Checkpoint">001E87</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E87</idno><idno type="wicri:Area/Ncbi/Merge">000E24</idno><idno type="wicri:Area/Ncbi/Curation">000E24</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E24</idno><idno type="wicri:doubleKey">0033-2917:2014:Bertocci M:behavioral:and:emotional</idno><idno type="wicri:Area/Main/Merge">003E49</idno><idno type="wicri:Area/Main/Curation">005820</idno><idno type="wicri:Area/Main/Exploration">005820</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth</title><author><name sortKey="Bertocci, M A" sort="Bertocci, M A" uniqKey="Bertocci M" first="M. A." last="Bertocci">M. A. Bertocci</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Bebko, G" sort="Bebko, G" uniqKey="Bebko G" first="G." last="Bebko">G. Bebko</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Olino, T" sort="Olino, T" uniqKey="Olino T" first="T." last="Olino">T. Olino</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Fournier, J" sort="Fournier, J" uniqKey="Fournier J" first="J." last="Fournier">J. Fournier</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Hinze, A K" sort="Hinze, A K" uniqKey="Hinze A" first="A. K." last="Hinze">A. K. Hinze</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Bonar, L" sort="Bonar, L" uniqKey="Bonar L" first="L." last="Bonar">L. Bonar</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Almeida, J R C" sort="Almeida, J R C" uniqKey="Almeida J" first="J. R. C." last="Almeida">J. R. C. Almeida</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Alpert Medical School, Brown University</s1><s2>Providence, RI</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Providence (Rhode Island)</settlement><region type="state">Rhode Island</region></placeName><orgName type="university">Université Brown</orgName></affiliation></author><author><name sortKey="Perlman, S B" sort="Perlman, S B" uniqKey="Perlman S" first="S. B." last="Perlman">S. B. Perlman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Versace, A" sort="Versace, A" uniqKey="Versace A" first="A." last="Versace">A. Versace</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Travis, M" sort="Travis, M" uniqKey="Travis M" first="M." last="Travis">M. Travis</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Gill, M K" sort="Gill, M K" uniqKey="Gill M" first="M. K." last="Gill">M. K. Gill</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Demeter, C" sort="Demeter, C" uniqKey="Demeter C" first="C." last="Demeter">C. Demeter</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospitals Case Medical Center/Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University Hospitals Case Medical Center/Case Western Reserve University</wicri:noRegion></affiliation></author><author><name sortKey="Diwadkar, V A" sort="Diwadkar, V A" uniqKey="Diwadkar V" first="V. A." last="Diwadkar">V. A. Diwadkar</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry and Behavioral Neuroscience, Wayne State University</s1><s2>Detroit, MI</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Detroit, MI</wicri:noRegion></affiliation></author><author><name sortKey="White, R" sort="White, R" uniqKey="White R" first="R." last="White">R. White</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry and Behavioral Neuroscience, Wayne State University</s1><s2>Detroit, MI</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Detroit, MI</wicri:noRegion></affiliation></author><author><name sortKey="Schirda, C" sort="Schirda, C" uniqKey="Schirda C" first="C." last="Schirda">C. Schirda</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Sunshine, J L" sort="Sunshine, J L" uniqKey="Sunshine J" first="J. L." last="Sunshine">J. L. Sunshine</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospitals Case Medical Center/Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University Hospitals Case Medical Center/Case Western Reserve University</wicri:noRegion></affiliation></author><author><name sortKey="Arnold, L E" sort="Arnold, L E" uniqKey="Arnold L" first="L. E." last="Arnold">L. E. Arnold</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, Ohio State University</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus, OH</wicri:noRegion></affiliation></author><author><name sortKey="Holland, S K" sort="Holland, S K" uniqKey="Holland S" first="S. K." last="Holland">S. K. Holland</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Cincinnati Children's Hospital Medical Center, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author><author><name sortKey="Kowatch, R A" sort="Kowatch, R A" uniqKey="Kowatch R" first="R. A." last="Kowatch">R. A. Kowatch</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>The Research Institute at Nationwide Children's Hospital</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>The Research Institute at Nationwide Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Birmaher, B" sort="Birmaher, B" uniqKey="Birmaher B" first="B." last="Birmaher">B. Birmaher</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Axelson, D" sort="Axelson, D" uniqKey="Axelson D" first="D." last="Axelson">D. Axelson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, Ohio State University</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus, OH</wicri:noRegion></affiliation></author><author><name sortKey="Youngstrom, E A" sort="Youngstrom, E A" uniqKey="Youngstrom E" first="E. A." last="Youngstrom">E. A. Youngstrom</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Psychology, University of North Carolina at Chapel Hill</s1><s2>Chapel Hill, NC</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Chapel Hill (Caroline du Nord)</settlement><region type="state">Caroline du Nord</region></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Findling, R L" sort="Findling, R L" uniqKey="Findling R" first="R. L." last="Findling">R. L. Findling</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospitals Case Medical Center/Case Western Reserve University</s1><s2>Cleveland, OH</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University Hospitals Case Medical Center/Case Western Reserve University</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Horwitz, S M" sort="Horwitz, S M" uniqKey="Horwitz S" first="S. M." last="Horwitz">S. M. Horwitz</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Child Psychiatry, New York University School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Fristad, M A" sort="Fristad, M A" uniqKey="Fristad M" first="M. A." last="Fristad">M. A. Fristad</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Psychiatry, Ohio State University</s1><s2>Columbus, OH</s2><s3>USA</s3><sZ>17 aut.</sZ><sZ>21 aut.</sZ><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus, OH</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, M L" sort="Phillips, M L" uniqKey="Phillips M" first="M. L." last="Phillips">M. L. Phillips</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>15 aut.</sZ><sZ>20 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j" type="main">Psychological medicine : (Print)</title><title level="j" type="abbreviated">Psychol. med. : (Print)</title><idno type="ISSN">0033-2917</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Psychological medicine : (Print)</title><title level="j" type="abbreviated">Psychol. med. : (Print)</title><idno type="ISSN">0033-2917</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adolescent Development (physiology)</term><term>Affective Symptoms (physiopathology)</term><term>Amygdala</term><term>Amygdala (physiopathology)</term><term>Amygdaloid nucleus</term><term>Behavioral Symptoms (physiopathology)</term><term>Behavioral disorder</term><term>Child</term><term>Emotion emotionality</term><term>Emotional disorder</term><term>Female</term><term>Functional magnetic resonance imaging</term><term>Growth</term><term>Humans</term><term>Latent class analysis</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Prefrontal Cortex (physiopathology)</term><term>Prefrontal cortex</term><term>Self regulation</term><term>Symptomatology</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Amygdale (système limbique) (physiopathologie)</term><term>Cortex préfrontal (physiopathologie)</term><term>Développement de l'adolescent (physiologie)</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Symptômes affectifs (physiopathologie)</term><term>Symptômes comportementaux (physiopathologie)</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Développement de l'adolescent</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adolescent Development</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Amygdale (système limbique)</term><term>Cortex préfrontal</term><term>Symptômes affectifs</term><term>Symptômes comportementaux</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Affective Symptoms</term><term>Amygdala</term><term>Behavioral Symptoms</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Trouble du comportement</term><term>Trouble de l'émotion</term><term>Cortex préfrontal</term><term>Noyau amygdalien</term><term>Amygdale</term><term>Symptomatologie</term><term>Autorégulation</term><term>Emotion émotivité</term><term>Analyse classes latentes</term><term>Croissance</term><term>Imagerie par résonance magnétique fonctionnelle</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Neuroimaging measures of behavioral and emotional dysregulation can yield biomarkers denoting developmental trajectories of psychiatric pathology in youth. We aimed to identify functional abnormalities in emotion regulation (ER) neural circuitry associated with different behavioral and emotional dysregulation trajectories using latent class growth analysis (LCGA) and neuroimaging. Method. A total of 61 youth (9-17 years) from the Longitudinal Assessment of Manic Symptoms study, and 24 healthy control youth, completed an emotional face n-back ER task during scanning. LCGA was performed on 12 biannual reports completed over 5 years of the Parent General Behavior Inventory 10-Item Mania Scale (PGBI-10M), a parental report of the child's difficulty regulating positive mood and energy. Results. There were two latent classes of PGBI-10M trajectories: high and decreasing (HighD; n=22) and low and decreasing (LowD; n=39) course of behavioral and emotional dysregulation over the 12 time points. Task performance was >89% in all youth, but more accurate in healthy controls and LowD versus HighD (p<0.001). During ER, LowD had greater activity than HighD and healthy controls in the dorsolateral prefrontal cortex, a key ER region, and greater functional connectivity than HighD between the amygdala and ventrolateral prefrontal cortex (p's<0.001, corrected). Conclusions. Patterns of function in lateral prefrontal cortical-amygdala circuitry in youth denote the severity of the developmental trajectory of behavioral and emotional dysregulation over time, and may be biological targets to guide differential treatment and novel treatment development for different levels of behavioral and emotional dysregulation in youth.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Pennsylvanie</li><li>Rhode Island</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li><li>Pittsburgh</li><li>Providence (Rhode Island)</li></settlement><orgName><li>Université Brown</li><li>Université de Caroline du Nord à Chapel Hill</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Bertocci, M A" sort="Bertocci, M A" uniqKey="Bertocci M" first="M. A." last="Bertocci">M. A. Bertocci</name></region><name sortKey="Almeida, J R C" sort="Almeida, J R C" uniqKey="Almeida J" first="J. R. C." last="Almeida">J. R. C. Almeida</name><name sortKey="Almeida, J R C" sort="Almeida, J R C" uniqKey="Almeida J" first="J. R. C." last="Almeida">J. R. C. Almeida</name><name sortKey="Arnold, L E" sort="Arnold, L E" uniqKey="Arnold L" first="L. E." last="Arnold">L. E. Arnold</name><name sortKey="Axelson, D" sort="Axelson, D" uniqKey="Axelson D" first="D." last="Axelson">D. Axelson</name><name sortKey="Bebko, G" sort="Bebko, G" uniqKey="Bebko G" first="G." last="Bebko">G. Bebko</name><name sortKey="Birmaher, B" sort="Birmaher, B" uniqKey="Birmaher B" first="B." last="Birmaher">B. Birmaher</name><name sortKey="Bonar, L" sort="Bonar, L" uniqKey="Bonar L" first="L." last="Bonar">L. Bonar</name><name sortKey="Demeter, C" sort="Demeter, C" uniqKey="Demeter C" first="C." last="Demeter">C. Demeter</name><name sortKey="Diwadkar, V A" sort="Diwadkar, V A" uniqKey="Diwadkar V" first="V. A." last="Diwadkar">V. A. Diwadkar</name><name sortKey="Findling, R L" sort="Findling, R L" uniqKey="Findling R" first="R. L." last="Findling">R. L. Findling</name><name sortKey="Findling, R L" sort="Findling, R L" uniqKey="Findling R" first="R. L." last="Findling">R. L. Findling</name><name sortKey="Fournier, J" sort="Fournier, J" uniqKey="Fournier J" first="J." last="Fournier">J. Fournier</name><name sortKey="Fristad, M A" sort="Fristad, M A" uniqKey="Fristad M" first="M. A." last="Fristad">M. A. Fristad</name><name sortKey="Gill, M K" sort="Gill, M K" uniqKey="Gill M" first="M. K." last="Gill">M. K. Gill</name><name sortKey="Hinze, A K" sort="Hinze, A K" uniqKey="Hinze A" first="A. K." last="Hinze">A. K. Hinze</name><name sortKey="Holland, S K" sort="Holland, S K" uniqKey="Holland S" first="S. K." last="Holland">S. K. Holland</name><name sortKey="Horwitz, S M" sort="Horwitz, S M" uniqKey="Horwitz S" first="S. M." last="Horwitz">S. M. Horwitz</name><name sortKey="Kowatch, R A" sort="Kowatch, R A" uniqKey="Kowatch R" first="R. A." last="Kowatch">R. A. Kowatch</name><name sortKey="Olino, T" sort="Olino, T" uniqKey="Olino T" first="T." last="Olino">T. Olino</name><name sortKey="Perlman, S B" sort="Perlman, S B" uniqKey="Perlman S" first="S. B." last="Perlman">S. B. Perlman</name><name sortKey="Phillips, M L" sort="Phillips, M L" uniqKey="Phillips M" first="M. L." last="Phillips">M. L. Phillips</name><name sortKey="Schirda, C" sort="Schirda, C" uniqKey="Schirda C" first="C." last="Schirda">C. Schirda</name><name sortKey="Sunshine, J L" sort="Sunshine, J L" uniqKey="Sunshine J" first="J. L." last="Sunshine">J. L. Sunshine</name><name sortKey="Travis, M" sort="Travis, M" uniqKey="Travis M" first="M." last="Travis">M. Travis</name><name sortKey="Versace, A" sort="Versace, A" uniqKey="Versace A" first="A." last="Versace">A. Versace</name><name sortKey="White, R" sort="White, R" uniqKey="White R" first="R." last="White">R. White</name><name sortKey="Youngstrom, E A" sort="Youngstrom, E A" uniqKey="Youngstrom E" first="E. A." last="Youngstrom">E. A. Youngstrom</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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